منابع مشابه
Cystic fibrosis from genotype to phenotype: review article
Cystic fibrosis (CF) is the most common autosomal recessive genetic disease, which is caused by defection in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR gene codes chloride channels to modulate the homeostasis of epithelial environments. Defective CFTR affects various organs such as the lungs, pancreas, intestine, liver and skin; however, lung impairment is the mai...
متن کاملPreface Plant Epigenetics: From Genotype to Phenotype
The Last Unicellular Common Ancestor (LUCA) has existed more than 1 billion years ago. During that time, the plant and animal kingdoms have evolved separately and adopted a multicellular system, with sophisticated pathways of development and capability for perfect adaptation to the environment. Today, in the era of genomics it is known that many developmental processes of plants and animals are...
متن کاملPreface Plant Epigenetics: From Genotype to Phenotype
The Last Unicellular Common Ancestor (LUCA) has existed more than 1 billion years ago. During that time, the plant and animal kingdoms have evolved separately and adopted a multicellular system, with sophisticated pathways of development and capability for perfect adaptation to the environment. Today, in the era of genomics it is known that many developmental processes of plants and animals are...
متن کاملFrom phenotype to genotype: a Bayesian solution.
The study of biological systems commonly depends on inferring the state of a 'hidden' variable, such as an underlying genotype, from that of an 'observed' variable, such as an expressed phenotype. However, this cannot be achieved using traditional quantitative methods when more than one genetic mechanism exists for a single observable phenotype. Using a novel latent class Bayesian model, it is ...
متن کاملCardiovascular Risk Stratification: From Phenotype to Genotype?
DOI: 10.5935/abc.20180010 Cardiovascular risk scores, such as the Framingham score, have been strongly recommended by clinical guidelines on the assessment of cardiovascular risk.1 However, several studies have shown limitations for their use,2,3 particularly in patients at intermediate risk, young patients with a definite family history, and women. Among different tools aimed at improving risk...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1995
ISSN: 1468-6244
DOI: 10.1136/jmg.32.10.839-a